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Original Research

Open Access

In Vivo Evaluation of Lesion Sterilization and Tissue Repair in Primary Teeth Pulp Therapy Using Two Antibiotic Drug Combinations

  • Jaya AR1
  • Praveen P2,*,
  • Anantharaj A2
  • Venkataraghavan K3
  • Prathibha Rani S2

1Department of Pedodontics, Rajarajeshwari Dental College, Bangalore

2Department of Pediatric and Preventive Dentistry, D.A.P.M.R.V Dental College, Bangalore

3Department of Pediatric and Preventive Dentistry, College of Dental Sciences & Research, Ahmedabad, Gujrat

DOI: 10.17796/jcpd.37.2.e5131jp6m1w33v66 Vol.37,Issue 2,March 2013 pp.189-192

Published: 01 March 2013

*Corresponding Author(s): Praveen P E-mail:


Aim : The purpose of this study is to evaluate and compare the clinical and radiographic effectiveness of Ciprofloxacin, Minocycline, Metronidazole combination with Ciprofloxacin, Minocycline and Tinidazole combination when used for Lesion Sterilization and Tissue Repair in primary teeth. Method: 25 healthy children, visiting Dept. of Pediatric & Preventive Dentistry, D.A.P.M.R.V.Dental College, Bangalore, India, aged between 6 - 9 years who were having 30 infected primary teeth are selected and divided into 2 groups. In Group A, a mixture of 3mix-MP Ciprofloxacin, Metronidazole and Minocycline was placed on the floor of the pulp chamber covering the root canal orifices. In Group B a mixture of Ciprofloxacin, Tinidazole and Minocycline was placed as a layer on the floor of the pulp chamber. The procedure was completed in a single visit. Post operative clinical evaluation was done after 1,6,12 and 24 months. Postoperative radiographic evaluation was done at 6,12 and 24 months. Results: No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption. Conclusion: After a 24 Month follow up, we can conclude that primary teeth with the periradicular lesions, can be conserved by using combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs.


Lesion Sterilization and Tissue repair, Primary tooth, pulp therapy, Antibiotics, Ciprofloxacin, Minocycline, Tinidazole

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Jaya AR,Praveen P,Anantharaj A,Venkataraghavan K,Prathibha Rani S. In Vivo Evaluation of Lesion Sterilization and Tissue Repair in Primary Teeth Pulp Therapy Using Two Antibiotic Drug Combinations. Journal of Clinical Pediatric Dentistry. 2013. 37(2);189-192.


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